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Spleno-extramedullary hematopoiesis. Spleen sections from T241-VEGF and T241-vector tumor-bearing mice were stained with H&E (A and B), or were double stained an anti-Ter119 antibody and propidium iodide (PI) (C and D). Dashed lines in panel B encircle white pulp (WP). RP = red pulp. Hematopietic cells from the erythrocyte lineage were labeled with Ter119 (green) and all cell nuclei were labeled with PI (red). Bar in panel A and B = 100 μm. Bar in C and D = 50 μm.
