Table 1.

Reversion rates of wild-type and MMR-deficient strains

Strain	Codon 22	Mismatch required, template/nascent		Reversion rate, ×10−6
		Top strand	Bottom strand	Wild type	msh2	msh3	msh6
YMH52	CGC	C/A	G/T	0.0024	1.7	0.0033	1.5
YMH53	AGC	A/A	T/T	<0.0001	<0.0001	<0.0001	<0.0001
YMH54	GGC	G/A	C/T	0.0024	5.6	0.0027	6.3
YMH55	TCC	C/C	G/G	0.0011	0.0012	0.0019	0.0012
YMH56	TTC	T/C	A/G	0.0001	0.0002	0.0001	0.0013
YMH57	TAC	A/C	T/G	0.0001	0.31	<0.0001	0.33

This table shows the reversion rates of CYC1 codon 22 to the wild-type codon (TGC) and the mismatches that would have to be tolerated for this reversion event to occur during replication.