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. 2010 Jan 15;5(1):e8741. doi: 10.1371/journal.pone.0008741

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Rats (n = 13) received systemic injections of vehicle or amphetamine (0.3, 1, and 3 mg/kg, i.p.) just prior to each session, except that in the last session, they received noncontingent intra-tubercle amphetamine (30 mM; 78 nl per infusion). A. Systemic 0.3 and 1 mg/kg amphetamine slightly increased active lever presses, whereas the 3 mg/kg dose markedly decreased lever presses. ^* P<0.001, significantly greater than its inactive lever presses and the active lever presses of the 3 mg/kg session. ^** P<0.005, significantly greater than its inactive lever presses and the active lever presses of the saline session. ^*** P<0.0005, significantly greater than its inactive lever presses and the active lever presses of all other sessions. B. Systemic 1 and 3 mg/kg amphetamine increased locomotor activity. ^* P<0.005, significantly greater than the values of the saline, 0.3 mg/kg and intra-tubercle sessions.