Table 1.

 Odds ratios and area under receiver operating characteristics curve for Cambridge type 2 diabetes risk score, Framingham offspring type 2 diabetes risk score, and genetic risk scores alone and in combination in Whitehall II study

Risk model	Odds ratio* (95% CI)	Area under receiver operating characteristics curve (95% CI)	Detection rate for 5% false positive rate	Detection rate for 10% false positive rate
Cambridge risk score	8.4 (5.1 to 13.9)	0.72 (0.69 to 0.76)	19.7 (14.1 to 25.3)	34.2 (27.5 to 40.9)
Framingham offspring risk score	18.2 (9.8 to 33.8)	0.78 (0.75 to 0.82)	30.6 (24.1 to 37.1)	43.0 (36.0 to 50.0)
Gene count score	1.7 (0.9 to 2.5)	0.54 (0.50 to 0.58)	6.5 (3.5 to 10.8)	9.9 (6.2 to 14.9)
Genetic risk function score	2.3 (1.5 to 3.8)	0.55 (0.51 to 0.59)	6.4 (3.5 to 10.8)	11.4 (7.4 to 16.6)
Cambridge risk score and gene count score	9.7 (5.4 to 17.4)	0.73 (0.69 to 0.76)	20.3 (15.0 to 26.5)	33.7 (27.2 to 40.6)
Cambridge risk score and genetic risk function score	7.9 (4.5 to 13.7)	0.73 (0.69 to 0.76)	21.8 (16.3 to 28.1)	32.2 (25.8 to 39.1)
Framingham offspring risk score and gene count score	11.2 (6.1 to 20.5)	0.78 (0.75 to 0.81)	29.7 (23.5 to 36.5)	42.6 (35.7 to 49.7)
Framingham offspring risk score and genetic risk function score	11.0 (6.0 to 20.1)	0.78 (0.74 to 0.81)	31.2 (24.9 to 38.1)	40.1 (33.3 to 47.2)

*Odds ratio for top versus bottom fifth.