Table 3.
 Prevalence and percentage of incident cases of type 2 diabetes in categories of predicted risk calculated by using phenotype based risk models alone, and same models with addition of genetic data
| Category of predicted risk | Proportion reclassified (%) | ||||
|---|---|---|---|---|---|
| <5% | 5-9.9% | 10-14.9% | >15% | ||
| Cambridge risk score | |||||
| Without genotype scores | 64/2257 (2.8) | 54/753 (7.2) | 48/328 (14.6) | 36/188 (19.2) | NA |
| With simple gene count score | 63/2226 (2.8) | 59/787 (7.5) | 41/317 (12.9) | 39/196 (19.9) | 322/3526 (9.9) |
| With genetic risk function | 57/2191 (2.6) | 61/824 (7.4) | 42/309 (13.6) | 42/202 (20.8) | 522/3526 (16.0) |
| Framingham offspring risk score | |||||
| Without genotype scores | 60/2403 (2.5) | 42/603 (7.0) | 31/261 (11.9) | 69/259 (26.6) | NA |
| With simple gene count score | 54/2385 (2.3) | 49/598 (8.2) | 32/265 (12.1) | 67/278 (24.1) | 210/3526 (6.0) |
| With genetic risk function | 55/2381 (2.3) | 54/614 (8.8) | 26/255 (10.2) | 67/276 (24.3) | 432/3526 (12.3) |
NA=not applicable.