Table 5.

 Net reclassification improvement based on addition of gene count score to Framingham offspring risk score

Predicted diabetes risk (Framingham offspring risk score)	No of people					Reclassified		Net correctly reclassified (%)
	<5%	5-10%	10-15%	>15%		Increased risk	Decreased risk
Plus gene count score—people without diabetes during follow-up (n=3324)
<5%	2295	48	0	0		121	64	−1.7
5-9.9%	36	482	43	0
10-14.9%	0	19	181	30
≥15%	0	0	9	181
Plus gene count score—people with diabetes during follow-up (n= 202)
<5%	52	8	0	0		14	11	1.5
5-9.9%	2	37	3	0
10-14.9%	0	4	24	3
≥15%	0	0	5	64

Net reclassification improvement 0.2% (95% CI −5.1 to 4.7); P=0.94.