Fig. 1.

Summary of human fH and its orthologues. (a) CCPs are represented by ovals sized to reflect the number of residues that each contains (51–62 residues); intermodular linker lengths (from three to eight residues) and ligand-binding regions are also summarised. Modules 10–15 are highlighted; the blow-up displays the number of residues in each CCP and the aligned sequences of linkers within orthologues. Also shown is an equivalent region (CCPs 3–7 out of nine CCPs) in human fH-related protein 5 (labelled fH-r5). (b) Sequence of CCPs 12 and 13 aligned based on their structures.¹⁹ β-Strands are indicated by arrows and by the first and the last residue numbers. Shaded boxes highlight identities. Underscored residues are exposed, an overscore identifies a buried residue, and a double overscore indicates a residue buried at the intermodular interface.²⁰