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. 1998 Dec 22;95(26):15492–15495. doi: 10.1073/pnas.95.26.15492

Figure 1.

Figure 1

The des-2 deg-3 operon. (A) Genomic organization. Arrows mark the site of spliced leader addition. Although the longer des-2 cDNA lacks a spliced leader, it starts at the same place as SL1-spliced variants that were identified from a random primed cDNA library. deg-3 is trans-spliced to the SL2 leader (7) (B) Alignment of DES-2 and DEG-3. The positions of the des-2 mutations (all of which result in premature termination) are indicated by asterisks. Codon changes are: hm5 (TGG to TGA), hm6 (TGG to TAG), and u695 (CAG to TAG). Thin underlining indicates the neurotransmitter gated-channel signature (24) and thick underlining indicates the putative transmembrane domains (see ref. 7). The two adjacent cysteines indicative of nAChR α subunits (25) are at amino acids 220 and 221 in DES-2.