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. 2009 Dec 9;17(12):1573–1581. doi: 10.1016/j.str.2009.10.012

Figure 2.

Figure 2

Crystal Structure of the DDR2 DS Domain-Collagen Complex

(A) Cartoon representation of the DS domain (cyan) and the collagen peptide (yellow, leading chain; orange, middle chain; red, trailing chain). The β strands of the DS domain are numbered sequentially. Disulfide bonds are in green. The side chains of the collagen GVMGFO motif are shown as sticks. Selected residues are labeled. X denotes norleucine.

(B) Orthogonal view of the complex, related to (A) by a 90° rotation about a vertical axis. The collagen peptide is viewed from N to C terminus. Loops at the top of the DS domain are labeled as follows: L1-3, β1-β2; L4, β3-β4; L5, β5-β6; and L6, β7-β8.

(C) Stereo view of the DDR2-collagen interface. Selected DDR2 and collagen residues are shown as sticks, in the same colors as in (A). The trailing collagen chain is shown as a semitransparent coil. Water molecules are shown as red spheres. Dashed lines indicate hydrogen bonds.