Skip to main content
. Author manuscript; available in PMC: 2010 Jan 15.
Published in final edited form as: J Comp Neurol. 1996 May 20;369(1):93–108. doi: 10.1002/(SICI)1096-9861(19960520)369:1<93::AID-CNE7>3.0.CO;2-F

Fig. 1.

Fig. 1

Spreading depression frequency. DC potential records shown were recorded from frontal neocortices during 3 hour period of recurrent spreading depression. Each pair of records represents an hour period. The upper record of each pair is from the left, experimental neocortex that experienced spreading depression, and the lower record of each pair is from the right, control neocortex, which never experienced spreading depression. Spreading depression was induced by micro-injection of 0.5 M KCl every 9 minutes for 3 hours within parietal cortex. At the conclusion of recording periods animals were allowed to survive for 3 days. Then they were re-anesthetized and processed for immunohistochemical staining (IS)for either OX-42 or anti-glial fibrillary acidic protein (GFAP). Sham control animals received similar injections of 0.5 M NaCl and never experienced spreading depression in either neocortex. Other groups of animals received pretreatment before spreading depression with drugs that modulated either eicosanoid or nitric oxide metabolism.