Fig. 4.

Effect of pretraining work as a covariate on genomewide linkage scans for change in work after 4 wk of exercise training in (FVB × B6) F₂ mice. Black line, genomewide linkage scan for change in work with no covariates; red line, genomewide linkage scan for change in work with pretraining work as an additive covariate; blue line, genomewide linkage scan for change in work with pretraining work as an interacting covariate. Significant and suggestive LOD thresholds are represented by top (LOD = 3.53) and bottom (LOD = 2.10) horizontal lines, respectively. LOD thresholds were determined by permutation testing using 1,000 permutations. ΔLOD ≥ 2.0 was found on chromosome 6 with pretraining as an interacting covariate.