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. 2009 Nov 11;103(1):25–37. doi: 10.1152/jn.00458.2009

Fig. 5.

Fig. 5.

GABAAR-mediated serial connections limit only GABACR-mediated input in rod and on cone BCs but also limit glycineR-mediated input in off cone BCs. Light (825 μm) was applied to all BC types. In rod and on cone BCs (A and B), when GABACRs were 1st blocked using TPMPA, adding bicuculline caused no increase in the Q of L-IPSCs (C and D), showing that the GABAAR-mediated serial connections only limit GABACR-mediated inputs (rod, n = 6, P < 0.05; on, n = 4, P < 0.001). In contrast, in off cone BCs, the addition of bicuculline still caused an increase in L-IPSC Q (D) due to the increase in glycine-receptor-mediated inputs (off, n = 4, P < 0.05). The change with bicuculline in the presence of TPMPA was significantly greater in off cone BCs than rod and on cone BCs (ANOVA P < 0.001, Scheffe on vs. off P < 0.001, rod vs. off P < 0.01). Scale bars are 200 ms and 5 pA (A and B; 10 pA (D).