Fig. 3.
Summary data for protocol 1 from 15 dogs confirm that right- and left-sided microinjections of NAL into pre-BötC (pBC) region fail to reverse the intravenous remi (REMI IV) induced depression of phrenic amplitude (PPA), prolongation of inspiratory duration (Ti) and expiratory duration (TE) while intravenous NAL (NAL IV) promptly reversed all REMI IV effects. To correct for the effects of time drift on phrenic respiratory rate (see text for details) from the onset of the protocol, changes in the variables were always analyzed relative to their immediate local control values, that is the value preceding each injection (e.g., preevent in Fig. 2). **, P < 0.01; ***, P < 0.001 for significant differences from no change.