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. 2009 Nov 11;103(1):479–489. doi: 10.1152/jn.00835.2009

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FIG. 6. — Young (3-wk-old) S845A mutants display a specific deficit in LTD. A: I-O curves generated by plotting FP slope against the amplitude of presynaptic fiber volley were not different between S845A mutants (closed symbols) and WT littermates (open symbols). B: PPF ratios measured at various ISIs did not differ between S845A mutants (closed symbols) and WT littermates (open symbols). C: LTP induced by delivering 4 trains of TBS was normal in the young S845A mutants. WTs: open symbols; S845A mutants: closed symbols. Representative traces taken right before (thin line) and 2 h after LTP induction (thick line) are shown to the right. D: LTD induced by a 15-min train of 1 Hz was virtually abolished in the young S845A mutants (closed symbols), but was normal in the WT littermates (open symbols). Representative traces taken right before (thin line) and 1 h after the onset of 1-Hz stimulation (thick line) are shown to the right.