FIGURE 4.

Aβ reduced several synaptic vesicle proteins. A, confocal micrographs showing the effect of chronic Aβ (500 nm, 24 h) on active synaptic proteins visualized by co-localization of synapsin-1 and AM1-43 (yellow and arrows). B, time course of Aβ effects on the level of several pre- and postsynaptic proteins. C, graphs showing the quantification of signal intensity obtained at different times of treatment. The faster effect of Aβ at 12 h was on presynaptic proteins. The bars are mean ± S.E. from three independent experiments (*, p < 0.05; **, p < 0.01).