FIGURE 7.

Comparison of the structures of various copper(I)-transporting ATPases. ATP-bound N-MNK (A) is compared with the structures of ATP-bound N-WLN (18) (B) and of the ATP-bound PN-domains of A. fulgidus CopA (17) (C). The common core of the N-domain is in dark gray in all panels. The unstructured loop of N-MNK and N-WLN, which is absent in CopA, and the P-domain in the structure of A. fulgidus CopA are in light gray. The structures in the three panels were superimposed by best fitting the coordinates of the backbone atoms of the corresponding residues in the alignment of Fig. 6. Only residues involved in secondary structure elements were taken into account. For clarity, the structures have been translated horizontally after superimposition. C-term, C-terminal; N-term, N-terminal.