Table 1.
USF1 hepatic gene expression signature sets data summary
| Ad-USF1 F | Ad-USF1 M | F2 ApoE F | F2 ApoE M | |
|---|---|---|---|---|
| Signature size (P < 0.05) | 265 | 345 | 2802 | 2613 |
| FDR at P< 0.05 | 0.22 | 0.15 | 0.30 | 0.30 |
| Overlap Ad-USF1 F (P-value) | 1.64 × 10−34 | >0.05 | 7.11 × 10−3 | |
| Overlap Ad-USF1 M (P-value) | 1.53 × 10−34 | >0.05 | 1.03 × 10−7 | |
| Enrichment | MEMN seta | MEMN seta | MEMN seta | MEMN seta |
| Obesity setb | Obesity setb | Obesity setb | Immune response | |
| Amino acid metabolism | Response to biotic stimulus | Intracellular organelle | Defense response | |
| Oxidoreductase activity | Defense response | Cytoplasm | Response to biotic stimulus | |
| Organic acid metabolism | Immune response | Cellular physiological processes | ||
| Carboxylic acid metabolism | Antigen presentation | Metabolism | ||
| Nitrogen compound metabolism | Antigen processing | Mitochondrion | ||
| Catalytic activity | Immunological synapse | Catalytic activity | ||
| Monoxygenase activity | Cytoplasm | Cellular metabolism | ||
| Immune response | Cytosol | |||
| Response to biotic stimulus |
Enrichment of GO and KEGG categories are significant at P < 0.05, after Benjamini correction for multiple comparisons. A detailed listing of the enrichment analysis results are provided in Supplementary Material, Table S3.
aMEMN, macrophage-enriched metabolic network (32).
bObesity set: see reference (34).