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. Author manuscript; available in PMC: 2010 Jan 15.
Published in final edited form as: J Am Soc Nephrol. 2008 Dec 31;20(1):23–35. doi: 10.1681/ASN.2008050456

Figure 1. Morphology of nephronophthisis.

Figure 1

(A) Renal ultrasound demonstrates increased echogenicity, loss of corticomedullary differentiation, and the presence of corticomedullary cysts. In contrast to polycystic kidney disease kidneys are not enlarged. (B) Renal histology in NPHP shows the characteristic triad of renal tubular cysts, tubular membrane disruption, and tubulointerstitial cell infiltrates with interstitial fibrosis and periglomerular fibrosis (B is courtesy of D. Bockenhauer, London).