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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Cell Death Differ. 2009 Mar 13;16(6):910–920. doi: 10.1038/cdd.2009.24

Figure 6.

Figure 6

Synaptojanin-1 levels are directly related to astroglial content in vivo. A, Representative western blots of total proteins extracted from brains of synaptojanin-1 knockout mice, Ts65Dn mice and their respective littermate controls. On the left, synaptojanin-1 knockout mouse brain (Synj1, -/-) shows lower levels of the astroglial markers GFAP, GLAST, GLT1, CD44 and SPARC than the brain of littermate controls (Synj1, +/+), but no changes are observed in the expression of the astroglial marker S100β and the neuronal markers Map2ab, beta III tubulin, synaptophysin and synaptotagmin. On the right, Ts65Dn mouse brain (Chr 16, Ts) shows higher levels of synaptojanin-1 expression and the astroglial marker GFAP than the brain of littermate controls (Chr16, +/+), but Map2ab expression is decreased and no changes were observed in the expression of any other neuronal or glial markers. B and C, Densitometric and statistic analyses of the experiments described in A. *, significant versus control, p<0.05.