Table I.
Kinases and phosphatases (with their correspondent GI numbers) whose phosphorylation state changes after incubation with retinoic acid or cytokines.
| GI number | Common phosphorylations (in RA and BMP+LIF but not in CON) | Also Induced by Forsk | PI3K-dependent * |
|---|---|---|---|
| 109464719 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | No | Yes |
| 109485997 | Mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 (NIK) | Yes | No |
| Common dephosphorylations (in CON but not in RA or BMP+LIF) | |||
| 94400809 | Synaptojanin-1 (Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1) | No | Yes |
| 94370595 | [Segment 1 of 2] Traf2 and NCK-interacting kinase (TNIK) | Yes | Yes |
| 94377177 | Receptor-type tyrosine-protein phosphatase zeta precursor (R-PTP-zeta) | Yes | Yes |
| 109475468 | Inositol polyphosphate-5-phosphatase B | Yes | Yes |
| 109499493 | BMP2 inducible kinase | Yes | No |
| Phosphorylation events specific to RA (only in RA) | |||
| 3241856 | DNA-dependent protein kinase catalytic subunit | No | Yes |
| 109493692 | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) | No | Yes |
| 109494796 | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) | No | Yes |
| 4558873 | Testis-enriched protein tyrosine phosphatase | No | Yes |
| 5733095 | Tyrosine kinase TYK2 | No | Yes |
| 20988799 | Ptk2 protein (Focal adhesion kinase 1)(FAK1) | No | Yes |
| 109475613 | Mitogen-activated protein kinase kinase kinase 6 (ASK2) | No | Yes |
| 109478244 | Mitogen-activated protein kinase kinase kinase kinase 5 (GCKR) | No | Yes |
| 109494196 | Ephrin type-A receptor 6 precursor (EHK-2) | No | No |
| 109503199 | Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) | No | No |
| 109503303 | Serine/threonine-protein kinase Nek1 (NimA-related protein kinase 1) | No | No |
| 109469632 | Inositol polyphosphate-5-phosphatase E | Yes | No |
| Dephosphorylation events specific to RA (present in CON and BMP+LIF but not in RA) | |||
| 94408289 | Insulin receptor substrate 4 | Yes | No |
| Phosphorylation events specific to BMP+LIF (only in BMP+LIF) | |||
| 203474 | Creatine kinase | No | N.D. |
| 12248185 | Nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate | No | N.D. |
| 20151205 | Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase | No | N.D. |
| 27882143 | Wnk4 protein | No | N.D. |
| 109463815 | Pantothenate kinase 1 (Pantothenic acid kinase 1) (mPank1) (mPank) | No | N.D. |
| 114145515 | Protein kinase N3 | No | N.D. |
| Dephosphorylation events specific to BMP+LIF (present in CON and RA but not in BMP+LIF) | |||
| 109499587 | Ephrin type-A receptor 5 precursor (EHK-1) | No | N.D. |
*
Events prevented by LY292004, a specific PI3K inhibitor
N.D. Not determined