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. Author manuscript; available in PMC: 2010 Dec 24.
Published in final edited form as: Neuron. 2009 Dec 24;64(6):807–827. doi: 10.1016/j.neuron.2009.11.006

Figure 4. LRRK2 accelerates somatic accumulation of A53T α-syn in neurons.

Figure 4

(A–H) Representative images show α-syn staining (green) in striatal neurons of A53T mice at 3 (A), 12 (B), and 20 months of age (C), and nTg mice at 20 months of age (D). F and G represent enlarged images with the white boxes in B and C. Nuclei were stained with Topro 3 (blue). Scale bars: 50 µm (A–D); 10 µm (E–H).

(I–P) Representative images reveal α-syn staining (green) in striatal neurons of 1-month old A53T (I), A53T/G2019S (J, L), A53T/LRRK2WT-L (M), and A53T/LRRK2WT (N, P) mice. Human LRRK2 was stained with an anti-HA antibody (red, K–L, O–P). Nuclei were stained with Topro 3 (blue). Scale bar: 10 µm.