Figure 1.

Known transcripts of CPEB3. Upper Panel: Representation of genomic DNA sequence. Boxes represented exons, and horizontal lines represented introns. Lower Panel: CPEB3 transcripts derived from alternative splicing. Ten transcripts were shown, with their accession numbers and types of tissue (if reported to the UniGene database) given to the right. The alternative splicings of exon 4, 5, 7 and 11 would generate different proteins products. The alternative splicings upstream of the start codon (exon 1-3) or downstream of the stop codon (exon 13) would give rise to different 5' and 3' UTRs, respectively. Dashed lines represented undetermined sequences. Partial sequence of transcript 2 (exon 5-7) was confirmed with the aid of PCR in a previous study [10], but its complete sequence was not documented in the UniGene database. Transcript 7 was a novel variant identified in the current study, of which the sequence upstream of exon 10 and downstream of exon 12 was not determined. Translational start codons and stop codons were annotated on top of the genomic DNA. Darkened boxed represented exons that could be alternatively spliced.