Figure 7. Glucose homeostasis in Sei1-null mice.

(A) Blood glucose levels were measured in groups of at least 4 male mice with the indicated genotypes maintained under ad libitum feeding. (B) Glucose tolerance test (GTT) on male mice (n = 8 per genotype), of 8 weeks of age. The area under the curve (AUC) for each genotype is represented to the right. (C) Insulin release test (IR) and its AUC performed in the same mice as in B (one week after the GTT). Values correspond to the average and s.d. Statistical differences were determined by the Student's t-test; *p<0.05; **p<0.01; and ***p<0.001.