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(a and b) In the setting of relapsing polychondritis there is chondrocyte necrosis with progressive cartilage replacement by granulation tissue (a and b). Indirect immunofluorescent testing using human trachea (autopsy specimen) shows positive granular staining of chondrocytes for IgG (c). C4d studies performed on paraffin embedded tissue will reveal nuclear decoration of chondrocytes (d)
