Fig. 3.

(a) Overview of numbers of differentially expressed genes identified in first microarray experiments using pooled total RNA when comparing aggressive to non-aggressive HNSCC tumors. Comparisons included all 18 aggressive tumors against all 18 non-aggressive tumors, as well as the corresponding comparisons for each anatomic site. Breakdown of the (b) 59 up-regulated and (c) 71 down-regulated genes identified in the initial global comparison of all 36 cases, according to whether they are seen in a single or several of the corresponding site-specific comparisons. (d) Breakdown of the up-regulated and down-regulated genes identified in each site specific comparison of differentially expressed genes based on numbers seen in each of the other site-specific comparisons