Table 1.
Histological studies defining the concomitant of a pituitary adenoma with a second sellar lesion
| No. | Pituitary adenoma | 2nd sellar lesion | Conclusion |
|---|---|---|---|
| 1 | Basophilic ACTH immunoreactive | PAS-positive mucin, cystic wall with columnar epithelium | ACTH-secreting pituitary adenoma coexisting with RCC |
| 2 | Chromophobic immunonegative (null cell) adenoma | Granoulomas formation without necrosis possibly secondary to sarcoidosis | Neurosarcoidosis within a null cell pituitary adenomaa |
| 3 | Chromophobic sparsely granulated GH immunoreactive, locally immunopositive for PRL, immunoreactive for NFP | Ganglion cells within a fibrillary substrate | Gangliocytoma combined with a GH-secreting pituitary adenoma |
| 4 | Chromophobic sparsely granulated GH immunoreactive | Well-circumscribed schwannoma Antoni A type with parallel-organised spindle-shaped cells around hypocellular areas (“Verocay bodies”) | GH-secreting pituitary adenoma coexisting with an intrasellar schwannoma |
| 5 | Chromophobic sparsely granulated GH immunoreactive, locally immunopositive for PRL and α-SU, immunoreactive for NFP | Large ganglion cells embedded in a dense neuropil substrate | Gangliocytoma combined with a GH-secreting pituitary adenoma |
| 6 | Chromophobic, GH immunoreactive, locally immunopositive for α-SU | Chromophobic PRL immunoreactive pituitary adenoma | Double adenoma consisting of a GH- and a PRL-secreting pituitary adenoma |
| 7 | Chromophobic, immunoreactive mainly for β-LH and locally for β-FSH | Cystic formation of Rathke’s cleft with a diameter of 0.1 cm, PAS-negative | Gonadotroph pituitary adenoma coexisting with RCC |
| 8 | Chromophobic sparsely granulated GH immunoreactive, locally immunopositive for PRL, immunoreactive for NFP | Ganglion cells embedded in a fibrillary substrate | Gangliocytoma combined with a GH-secreting pituitary adenoma |
α-SU α-subunit of glycoprotein hormones, β-FSH β-follicle stimulating hormone, β-LH β-luteinizing hormone, ACTH adrenocorticotropic hormone, GH growth hormone, NFP neurofilament protein, PAS periodic acid-Shiff, PRL prolactin, RCC Rathke’s cleft cyst
aThe final diagnosis of neurosarcoidosis was determined 3 years after surgery when the pulmonary disease was verified