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. 2009 Nov 23;158(8):1884–1894. doi: 10.1111/j.1476-5381.2009.00494.x

Figure 5.

Figure 5

The effect of genotype [soluble catechol-O-methyltransferase (S-COMT) deficiency or catechol-O-methyltransferase (COMT) knock-out] on the AUC0–120 min of striatal and prefrontal cortex (PFC) levels of L-DOPA (A), 3-O-methyl DOPA (3-OMD) (B), dopamine (C), dihydroxyphenylacetic acid (DOPAC) (D) and HVA (E) after oral administration of L-DOPA and carbidopa (10 mg·kg−1 and 30 mg·kg−1 respectively). The data represent group means ± SEM. +P < 0.05 and ++P < 0.01 differ significantly from corresponding male. #P < 0.05, ##P < 0.01 and ###P < 0.001 differ significantly from corresponding S-COMT-deficient mice. *P < 0.05, **P < 0.01 and ***P < 0.001 differ significantly from corresponding wild-type (WT) mice. n (male/female) = 13/13 (WT), 6/7 (S-COMT −/−) and 6/7 (COMT −/−).