Table 1.
Parameters for voltage dependence of activation and inactivation of rNav1.2a expressed in Xenopus laevis oocytes
| Concentration | CTRL | 0.1 nM | 1 nM | 10 nM | 100 nM | 500 nM |
|---|---|---|---|---|---|---|
| n | 56 | 12 | 10 | 10 | 10 | 14 |
| Activation | ||||||
| V1/2 (mV) | −40.9 ± 0.19 | −36.0 ± 0.26# | −45.4 ± 0.15 | −41.2 ± 0.16 | −37.1 ± 0.24# | −30.8 ± 0.22*# |
| k (mV) | 4.2 ± 0.16 | 3.6 ± 0.23 | 3.0 ± 0.13 | 3.5 ± 0.14 | 4.4 ± 0.21 | 5.6 ± 0.19 |
| Fast inactivation | ||||||
| V1/2 (mV) | −42.0 ± 0.87 | −36.7 ± 0.64# | −46.8 ± 0.74 | −40.9 ± 1.02 | −41.2 ± 1.17 | −33.3 ± 0.97*# |
| k (mV) | 5.6 ± 0.65 | 5.9 ± 0.48 | 6.4 ± 0.56 | 6.0 ± 0.76 | 5.8 ± 0.91 | 8.4 ± 0.74* |
| Slow inactivation | ||||||
| V1/2 (mV) | −51.9 ± 0.58 | −41.7 ± 0.37*# | −55.6 ± 0.46 | −51.6 ± 0.94 | −51.1 ± 0.54 | −38.2 ± 0.66*# |
| k (mV) | 5.4 ± 0.43 | 5.7 ± 0.26 | 5.6 ± 0.35 | 5.3 ± 0.52 | 5.4 ± 0.24 | 6.9 ± 0.41 |
*
P < 0.05; significant difference between control and Buthus martensi Karsch (BmK) AS values; one-way anova.
#
P < 0.05; significant difference between BmK AS at 1 nM and the other concentrations; one-way anova.