Table 2.

Parameters for voltage dependence of activation, inactivation and recovery of the ND7-23 VGSCs

Concentration	CTRL	0.1 nM	1 nM	10 nM	100 nM
n	46	12	10	12	12
Activation
V1/2 (mV)	−21.8 ± 0.23	−31.3 ± 0.46*	−30.0 ± 0.54*	−25.5 ± 0.97	−39.9 ± 0.61*
k (mV)	7.7 ± 0.28	7.0 ± 0.35	6.7 ± 0.41	6.1 ± 0.53	9.5 ± 0.56
Fast inactivation
V1/2 (mV)	−24.0 ± 0.34	−31.7 ± 0.38	−28.7 ± 0.29	−25.5 ± 0.48	−31.8 ± 1.15
k (mV)	8.2 ± 0.27	9.3 ± 0.28	9.3 ± 0.22	8.3 ± 0.38	14.0 ± 0.77*
Slow inactivation
V1/2 (mV)	−42.1 ± 0.95	−57.0 ± 0.59*	−48.6 ± 0.87	−41.0 ± 1.22	−76.9 ± 0.56*
k (mV)	10.8 ± 0.54	12.5 ± 0.38	12.3 ± 0.33	11.8 ± 0.49	13.0 ± 0.26
Recovery
V1/2 (mV)	−98.1 ± 4.04	−110.0 ± 0.89*	−101.1 ± 1.10	−103.8 ± 2.22	−109.0 ± 1.02*
k (mV)	10.8 ± 3.38	12.9 ± 0.99	10.9 ± 0.92	11.0 ± 2.06	9.7 ± 0.95

^*P < 0.05; significant difference between control and BmK AS; one-way anova.

BmK, Buthus martensi Karsch; VGSC, voltage-gated sodium channel.