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Ratio between contractions induced by phenylephrine before and after incubation of aortic rings with L-NAME (10−4 M). This ratio is shown as NO bioavailability (%) and contractions before L-NAME were set to 100%. NO, nitric oxide; SHR, spontaneously hypertensive rats; WKY, Wistar-Kyoto rats; Z0.5, SHR treated with zofenopril 0.5 mg·kg−1 per day; Z10, SHR treated with zofenopril 10 mg·kg−1 per day. *P < 0.05 compared with SHR. #P < 0.05 compared with WKY.
