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. 2009 Nov 16;158(8):1911–1921. doi: 10.1111/j.1476-5381.2009.00491.x

Table 4.

Effects of zofenopril on ACE activity in plasma, aorta and heart

ACE activity [nmol HL·(mg protein)−1·min−1] SHR Z0.5 Z10 WKY
PLASMA 2.44 ± 0.25# 1.86 ± 0.12 0.41 ± 0.09* 1.09 ± 0.23
AORTA 5.05 ± 0.58# 2.49 ± 0.35* 1.45 ± 0.42* 1.97 ± 0.64
HEART 0.052 ± 0.01# 0.022 ± 0.01* 0.015 ± 0.00* 0.012 ± 0.00

Values are means ± SEM.

*

P < 0.05 compared with SHR;

#

P < 0.05 compared with WKY.

SHR, spontaneously hypertensive rats; Z0.5, SHR treated with zofenopril 0.5 mg·kg−1 per day; Z10, SHR treated with zofenopril 10 mg·kg−1 per day; WKY, Wistar-Kyoto rats.