Table 1.
Noncompartmental pharmacokinetic parameters of microemulsion and long-chain triglyceride emulsion (LCT) propofol following zero-order infusion in beagle dogs
| Parameter |
Microemulsion propofol |
LCT propofol |
||||
|---|---|---|---|---|---|---|
| 0.75 mg·kg−1·min−1 | 1.00 mg·kg−1·min−1 | 1.25 mg·kg−1·min−1 | 0.75 mg·kg−1·min−1 | 1.00 mg·kg−1·min−1 | 1.25 mg·kg−1·min−1 | |
| λZ (min−1) | 0.00377 ± 0.00175 | 0.00662 ± 0.00275 | 0.00603 ± 0.00221 | 0.00383 ± 0.00277 | 0.00615 ± 0.00295 | 0.00433 ± 0.00203 |
| tmax (min) | 20.0 ± 0 | 20.0 ± 0 | 20.0 ± 0 | 20.0 ± 0 | 20.0 ± 0 | 20.0 ± 0 |
| Cmax ((g·mL−1) | 8.4 ± 2.7 | 12.1 ± 2.4 | 15.4 ± 2.0 | 9.7 ± 3.2 | 15.6 ± 4.0 | 19.4 ± 2.9 |
| AUClast ((g·mL−1·min) | 238.1 ± 64.2 | 358.1 ± 84.2 | 427.6 ± 61.8 | 267.2 ± 64.5 | 407.7 ± 88.5 | 476.6 ± 69.8 |
| AUCinf ((g·mL−1·min) | 258.3 ± 59.8 | 367.9 ± 84.4 | 450.9 ± 72.4 | 296.3 ± 65.9 | 422.3 ± 95.1 | 503.2 ± 75.3 |
| AUC%Extrap (%) | 8.3 ± 5.4 | 2.8 ± 1.5 | 4.8 ± 5.4 | 9.5 ± 9.6 | 3.3 ± 2.0 | 5.2 ± 3.5 |
| Vz (L·kg−1) | 21.1 ± 12.6 | 10.8 ± 6.8 | 12.9 ± 11.6 | 21.8 ± 17.9 | 10.2 ± 6.5 | 14.6 ± 7.6 |
| Cl (mL·min−1·kg−1) | 60.5 ± 12.1 | 56.7 ± 11.9 | 57.0 ± 10.8 | 52.7 ± 10.8 | 49.1 ± 8.7 | 50.6 ± 7.0 |
| MRTlast (min) | 32.9 ± 7.7 | 30.1 ± 6.6 | 30.8 ± 4.4 | 31.4 ± 6.8 | 27.6 ± 6.0 | 26.5 ± 5.2 |
| Vss (L·kg−1) | 6.0 ± 3.7 | 2.6 ± 0.9 | 3.7 ± 3.4 | 6.8 ± 7.8 | 2.3 ± 0.8 | 3.1 ± 1.6 |
Data are expressed as mean ± SD (n= 10, each infusion rate).
λZ, terminal elimination rate constant; tmax, time at maximal concentration; Cmax, maximal concentration; AUClast, area under the curve from administration to the last measured concentration; AUCinf, area under the curve from administration to infinity; AUC%Extrap, percentage of the extrapolated area under the curve at the total area under the curve; Vz, volume of distribution; MRTlast, Mean residence time to the last measured concentration; Vss, volume of distribution at steady state.