Figure 3.

3,5-dibromo-L-phenylalanine (3,5-DBr-L-Phe) depresses pentylenetetrazole (PTZ)-induced seizures. Each group of animals received an injection of 3,5-DBr-L-Phe (30 mg·kg⁻¹, i.p.) or equal volumes of saline 15 min prior to PTZ administration (60 mg·kg⁻¹, i.p.). (A) seizure intensity at a given time (bin interval 30 s) during the 20 min observation period. See Methods for seizure intensity scoring. Data are presented as mean ± SE. (B) Box plots showing the duration of seizures of a given intensity (score) during the experiment. ⁺P < 0.05 and ^‡P < 0.01 versus saline (Mann–Whitney Rank Sum Test) for both (A) and (B), n= 10 per group.