Table 1.

Old Order Amish subjects included in linkage analysis

Subjects	Analysis categories
	Mentally healthy	Unknowns
Pedigrees 110, 210, 310, 410
≥25 years old	138	85
≥35 years old	109	114
≥45 years old	74	149
≥55 years old	52	171
Pedigree 110 only
≥25 years old	45	32
≥35 years old	37	40
≥45 years old	31	46
≥55 years old	23	54

The category of unknowns includes individuals of unknown phenotype, individuals with psychiatric diagnoses other than BPI, and individuals who are mentally healthy but are younger than the particular age cut-off used in analyses. BPI individuals are not included in the unknown phenotype category. In pedigrees 110, 210, 310, and 410, 39 people were diagnosed with BPI, eight with BPII, 21 with recurrent depressive disorder, two with unipolar depressive disorder, and 15 with other psychiatric illness. In pedigree 110 alone, 18 people were diagnosed with BPI, two with BPII, 10 with major depressive disorder, and five with other psychiaric illness. Note: the individuals used in these linkage analyses represent only a subset of the entire Amish bipolar pedigrees because only nuclear families and subpedigrees containing a sibling with BPI were included.