Table 5.

Interaction of PP2A gene haplotypes with proliferative breast disease

Gene				Prolif- erative disease	Copies of Haplo- type	Odds ratio	95% Confidence Interval	P value
Haplotype		Cases	Controls
PPP2R1A
A:		150	416	No	≤ 1	1
	C	72	116	No	2	1.86	1.3 – 2.7	0.001
	Recessive	147	257	Yes	≤ 1	1.73	1.3 – 2.3	0.0003
	risk	78	95	Yes	2	2.44	1.7 – 3.5	0.000003
B:		127	199	No	0	1
	CTAGGCA	44	124	No	≥ 1	0.503	0.33 – 0.8	0.002
	Dominant	123	145	Yes	0	1.32	0.9 – 1.9	0.12
	protection	43	85	Yes	≥ 1	0.82	0.5 – 1.3	0.37
PPP2R2A
C:		84	231	No	≤ 1	1
	A	139	304	No	2	1.29	0.9 – 1.8	0.13
	Recessive	85	161	Yes	≤ 1	1.53	1.1 – 2.2	0.025
	risk	140	192	Yes	2	2.15	1.5 – 3.0	0.00002
D:		139	304	No	0	1
	G	84	231	No	≥ 1	0.778	0.56 – 1.1	0.13
	Dominant	140	192	Yes	0	1.67	1.2 – 2.3	0.001
	protection	85	161	Yes	≥ 1	1.19	0.84 – 1.7	0.32
PPP2R5E
E:		202	482	No	0	1
	GCT	20	50	No	≥ 1	1.01	0.59 – 1.8	0.96
	Dominant	190	320	Yes	0	1.49	1.1 – 1.9	0.003
	risk	34	32	Yes	≥ 1	2.67	1.6 – 4.5	0.0002
F:		67	153	No	≤ 1	1
	GA	155	377	No	2	0.878	0.61 – 1.3	0.48
	Recessive	75	92	Yes	≤ 1	1.94	1.3 – 3.0	0.002
	protection	149	258	Yes	2	1.306	0.9 – 1.9	0.16