Table 2.
Effect of maternal parity and postnatal age on mitochondrial gene expression (uncoupling protein 1/2 (UCP1/2), peroxisome proliferator-activated receptor α (PPARA) and PPARG) and IGF1R and IGF2R mRNAs. Data are given as means with their standard errors (n=5–9 per group). Significant effects of maternal parity and postnatal age were analysed using a two-way ANOVA. Data are presented as means±s.e.m
| 1 day of age | 30 days of age | |||
|---|---|---|---|---|
| Nulliparous | Multiparous | Nulliparous | Multiparous | |
| UCP1 mRNA (a.u) | 1·0±0·13 | 1·0±2·26 | 0·01±0·0∥ | 0·012±0·0∥ |
| UCP2 mRNA (a.u) | 1·9±0·28* | 1·0±0·12† | 1·14±0·06‡ | 1·32±0·13‡ |
| UCP1 (% ref) | 118±3·8* | 100±2·6† | ND*,∥ | 10·4±2·6†,∥ |
| Leptin mRNA (a.u) | 1·9±0·2* | 1·0±0·2† | 1·6±0·3* | 0·5±0·04† |
| Adiponectin mRNA (a.u) | 0·9±0·1 | 1·0±0·23 | 3·1±0·6*,§ | 1·0±0·13† |
| IL6 mRNA (a.u) | 1·38±0·4 | 1·0±0·23 | 10·48±2·2*,∥ | 1·38±1·0† |
| TNFα mRNA (a.u) | 0·7±0·2 | 1·0±0·4 | 1·8±0·6 | 7·7±6·7 |
| GR mRNA (a.u) | 1·9±0·4* | 1·0±0·3† | 36·4±9·5*,∥ | 1·0±0·4†,‡ |
| HSD11B1 mRNA (a.u) | 1·0±0·6 | 1·0±0·3 | 0·3±0·1 | 1·2±0·5 |
| HSD11B2 mRNA (a.u) | 2·7±0·5* | 1·0±0·1† | 0·8±0·2‡ | 1·0±0·6 |
| Insulin receptor mRNA (a.u) | 1·7±0·2* | 1·0±0·3† | 0·5±0·1*,‡ | 1·0±0·2†,‡ |
| IGFBP3 mRNA (a.u) | 1·8±0·7 | 1·0±0·3 | 0·4±0·1 | 1·0±0·2 |
| PPARA mRNA (a.u) | 1·1±0·18 | 1·0±0·09 | 0·82±0·14‡ | 0·43±0·06‡ |
| PPARG mRNA (a.u) | 4·0±1·1 | 1·0±0·22 | 0·54±0·17‡ | 0·34±0·12‡ |
| IGF1R mRNA (a.u) | 1·6±0·12* | 1·0±0·08† | 0·1±0·05§ | 0·1±0·02§ |
| IGF2R mRNA (a.u) | 1·4±0·4 | 1·0±0·2 | 0·56±0·2§ | 0·3±0·2§ |
*,†Different superscripts within an age group denote statistically significant effect of parity (P<0·05). ‡P<0·05, §P<0·01, ∥P<0·005 denote statistically significant effect of postnatal age within parity group. PAT, perirenal–abdominal adipose tissue; ND, not detected; a.u, arbitrary units.