Table 2.
Association of testosterone with QTc, QT and RR interval
| Testosterone | QTc-interval in ms (95% CI)a | QT-interval in ms (95% CI)b | RR-interval in ms (95% CI)a | |
|---|---|---|---|---|
| Rotterdam study (n = 445) | Log-transformation | −6.5 (−23.7; 10.8) | 5.9 (−8.2; 20.1) | 149.8 (30.6; 269.1) |
| Tertiles | ||||
| 1 | Reference | Reference | Reference | |
| 2 | 3.8 (−4.1; 11.7) | 5.5 (−0.8; 11.9) | 29.2 (−27.3; 85.8) | |
| 3 | −5.9 (−13.8; 2.1) | −2.4 (−8.8; 4.0) | 42.4 (−14.3; 99.2) | |
| P value for linear trend | 0.132 | 0.419 | 0.143 | |
| SHIP (n = 1,428) | Log-transformation | −7.9 (−15.3; −0.6) | −3.4 (−9.2; 2.4) | 55.9 (5.2; 106.6) |
| Tertiles | ||||
| 1 | Reference | Reference | Reference | |
| 2 | −0.7 (−3.6; 2.2) | 1.5 (−0.8; 3.9) | 24.0 (3.8; 44.1) | |
| 3 | −2.9 (−5.9; 0.1) | −0.6 (−3.0; 1.8) | 31.3 (10.3; 52.3) | |
| P value for linear trend | 0.061 | 0.623 | 0.004 |
CI confidence interval
aAdjusted for age, time of blood withdrawal, diabetes, hypertension, myocardial infarction, potassium, calcium, BMI, dehydroepiandrosterone sulfate (DHEAS) and in the Rotterdam Study also for heart failure
bAdjusted for age, time of blood withdrawal, diabetes, hypertension, myocardial infarction, potassium, calcium, BMI, DHEAS, RR interval and in the Rotterdam study also for heart failure
Testosterone in nmol/l. For the Rotterdam study the tertiles were defined as (1) ≤9.9; (2) 10.0–12.6; (3) ≥12.7. For SHIP the tertiles were defined as (1) ≤13.9; (2) 14.0–18.6; (3) ≥18.7
The bold values indicate significance at P < 0.05