Table 1.
Effects of GM on hepatic damage induced by APAP in mice
| Treatment | Dose (mg/kg) |
Histopathological scores |
||||||
| 0 | 1 | 2 | 3 | 4 | 5 | Average | ||
| Saline + Saline | - | 10 | 0 | 0 | 0 | 0 | 0 | 0.0 |
| APAP + Saline | - | 0 | 0 | 1 | 3 | 4 | 2 | 3.7 |
| APAP + GM | 200 | 0 | 4 | 3 | 2 | 1 | 0 | 2.0b |
| 100 | 0 | 3 | 3 | 2 | 2 | 0 | 2.3a | |
| 50 | 0 | 2 | 3 | 2 | 2 | 1 | 2.7 | |
| APAP + NAC | 300 | 0 | 3 | 4 | 2 | 1 | 0 | 2.1b |
APAP was given intraperitoneally with a single dose of 300 mg/kg. GM was given orally with a single dose of 200, 100 or 50 mg/kg. Livers were graded from 0 to 5 as described in Materials and Methods. Each value is the number of animals with grading changes.
a
P < 0.05,
b
P < 0.01 significantly different when compared with APAP alone group. GM: Gentiana manshurica Kitagawa; APAP: Acetaminophen.