Table 2.
PicTar-predicted targets common to miR-134 and miR-183
| Human RefSeq | miR-134 score | miR-183 score | Annotation |
|---|---|---|---|
| NM_012082 | 6.49 | 3.37 | Zinc finger protein, multitype 2 (ZFPM2) |
| NM_002211 | 5.61 | 5.93 | Integrin, beta 1 (ITGB1), transcript variant 1A |
| NM_019063 | 4.56 | 2.15 | Echinoderm microtubule-associated protein-like 4 (EML4) |
| NM_016279 | 4.12 | 3.51 | ZFPM2 |
| NM_004349 | 3.97 | 2.27 | Core-binding factor, runt domain, alpha subunit 2 (CBFA2T1), transcript variant 1 |
| NM_175634 | 3.97 | 2.27 | CBFA2T1 transcript variant 2 |
| NM_175635 | 3.97 | 2.27 | CBFA2T1 transcript variant 3 |
| NM_175636 | 3.97 | 2.27 | CBFA2T1 transcript variant 4 |
| NM_003016 | 3.9 | 2.22 | Splicing factor, arginine/serine-rich 2 (SFRS2, SC35) |
| NM_004384 | 3.21 | 2.91 | Casein kinase 1, gamma 3 (CSNK1G3) |
| NM_173683 | 2.99 | 2.48 | Chromosome 8 open reading frame 21 (C8orf21) |
| NM_182485 | 2.38 | 1.46 | Cytoplasmic polyadenylation element binding protein 2 (CPEB2), transcript variant B |
| NM_182646 | 2.38 | 1.46 | CPEB2 transcript variant A |
| NM_003605 | 2.36 | 2.97 | O-linked N-acetylglucosamine (GlcNAc) transferase (OGT), transcript variant 3 |
| NM_006561 | 2.32 | 1.34 | CUG triplet repeat, RNA binding protein 2 (CUGBP2) |
| NM_021038 | 2.22 | 1.55 | Muscle blind-like (Drosophila; MBNL1), transcript variant 1 |
| NM_207292 | 2.22 | 1.55 | MBNL1 transcript variant 2 |
| NM_207293 | 2.22 | 1.55 | MBNL1 transcript variant 3 |
| NM_207294 | 2.22 | 1.55 | MBNL1 transcript variant 4 |
| NM_207295 | 2.22 | 1.55 | MBNL1 transcript variant 5 |
| NM_207296 | 2.22 | 1.55 | MBNL1 transcript variant 6 |
| NM_207297 | 2.21 | 1.54 | MBNL1 transcript variant 7 |
ZPFM2 and CBFA2T1 are transcription factors (CBFA2T1 is involved with controlling oxidative stress and inflammation (Martinez et al. 2004)); integrin-β, casein kinase 1G3, and OGT are signaling molecules (integrin-β is involved in regulating sheer stress (Chen et al. 1999)); OGT controls heat shock reactions (Sohn et al. 2004). MBNL1, CUGBP2, and SFRS2 are known regulators of alternative splicing (CUGBP2 is involved in RNA editing (Anant et al. 2001); SC35 accumulates in the PFC following acute stress and regulates the stress-induced alternative splicing of AChE mRNA in brain neurons (Meshorer et al. 2005))