Schematic illustration showing expression patterns of Six family genes during murine tooth development. (A) Expression patterns at E10.5. (B) Expression patterns in the lower incisor and molar tooth germs at the bud stage (E13.5). (C) Expression patterns in the upper incisor and lower molar tooth germs at the late cap (E16.5) and the bell (E18.5) stages. (D) Expression patterns in the upper incisor germs at E18.5 along the anterior–posterior (apical–proximal) axis. Six1 expression, orange; Six2 expression, pink; Six4 expression, green; Six5 expression, blue; Md, mandible; Mx, maxilla; Mes, mesenchyme; OE, oral epithelium; DE, dental epithelium; DM, dental mesenchyme; DF, dental follicle; IEE, inner enamel epithelium; OEE, outer enamel epithelium; O, odontoblast; SR, stellate reticulum; DP, dental papilla; A, anterior; P, posterior.