Table 1.
c-Rel deficiency selectively blocks intra-thymic development of Foxp3+ regulatory T cells, but not that of Foxp3− T cells.
| Day | Mice (n=6) | Thymocytes per mouse (× 10−5) | CD4+CD8− (% of thymocytes) | CD4+CD8− CD25+ (%)a, b | CD4+CD8− Foxp3+ (%)a, b | CD4+CD8− CD25+Foxp3+ (%)a, b | CD4+CD8− CD25− Foxp3− (%)a |
|---|---|---|---|---|---|---|---|
| 3 | WT | 100±15 | 17±2.3 | 2.0±0.4 | 1.2±0.2 | 0.8±0.2 | 97.8±1.7 |
| c-Rel−/− | 80±8 | 17±1.8 | 0.4±0.2 | 0.2±0.1 | 0.1±0.1 | 99.5±1.5 | |
| 7 | WT | 600±80 | 16±2.2 | 4.8±1.2 | 4.7±0.5 | 2.6±0.9 | 93.7±1.5 |
| c-Rel−/− | 500±75 | 10±2 | 0.9±0.3 | 0.5±0.2 | 0.3±0.1 | 97.2±0.9 | |
| 21 | WT | 1,100±120 | 14±1.5 | 6.2±0.8 | 5.2±0.9 | 4.1±0.8 | 91.5±1.4 |
| c-Rel−/− | 1,000±110 | 13±1.2 | 0.8±0.3 | 1.2±0.3 | 0.5±0.2 | 97.8±0.8 | |
| 42 | WT | 1,900±250 | 6.5±0.9 | 11.9±1.5 | 6.2±1.2 | 2.7±0.9 | 86.6±2.9 |
| c-Rel−/− | 1,700±220 | 6±1.3 | 0.7±0.2 | 0.7±0.7 | 0.2±0.1 | 99.5±1.6 |
a
% of CD4+ T cells.
b
The differences between WT and c-Rel−/− groups are statistically significant (p<0.001) for all days.