Table 1.
Microsatellite mutational biases due to loss of specific MMR gene functions
| MMR gene deficiency | Species | STR | Del:Ins | Reference |
|---|---|---|---|---|
| MSH2 | mouse | (G/C)7–8 | 4:1 | (15) |
| yeast | (GT/CA)16.5 | 1:1 | (12) | |
| MSH6 | mouse | (G/C)7–8 | 1:1 | (15) |
| yeast | (G/C)18 | 3:1 | (12) | |
| (GT/CA)16.5 | 1:3.5 | (12) | ||
| MSH3 | mouse | (G/C)7–8 | 2:1 | (15) |
| yeast | (GT/CA)16.5 | 4:1 | (12) | |
| MLH1 | mouse | (G/C)7–8 | 4:1 | (15) |
| (A/T)23–27 | 19:1 | (17) | ||
| (AC/TG)22–33 | 2:1 | (17) | ||
| PMS2 | mouse | (G/C)7–8 | 2:1 | (15) |
| (A/T)23–27 | 6:1 | (17) | ||
| (AC/TG)22–33 | 1:2 | (17) | ||
| human | (GT/CA)10 | 1:11 | unpublished observations | |
| (TTCC/AAGG)9 | 1:21 | (14) | ||
| (TTTC/AAAG)9 | 1:4 | (14) | ||