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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Clin Cancer Res. 2010 Jan 12;16(2):600–609. doi: 10.1158/1078-0432.CCR-09-1979

Figure 4. Both paclitaxel treatment and transfection of SLPI.HA activate ERK.

Figure 4

A. Paclitaxel pulse induces phospho-ERK. Paclitaxel (6ug/mL) was pulsed over 10min to 4hr prior to cell harvesting. A biphasic activation is observed in the resistant cells. B. Paclitaxel and SLPI induce ERK activation, but only paclitaxel resistance is associated with activation of AKT in the A2780 cell set. Two panels of pERK are presented, independent experiments, one showing a darker view and one a shorter exposure. Representative data of at least three independent experiments are shown. GAPDH represents the loading control. C. CR012 reduces activation of ERK and AKT.