Smad4 complete knockout mice |
Tumors throughout the gastrointestinal tract |
All type of cells |
Gastrointestinal epithelial cells |
Alone 51, 53 or with Apc+/-50, 64, 65, elf+/-58-60
|
Tissue-specific Smad4 conditional knockout mice |
Tumors throughout the gastrointestinal tract |
T cells |
Gastrointestinal epithelial cells |
Alone 107
|
Pancreatic ductal adenocarcinomas |
Pancreatic progenitor cells |
Pancreatic ductal epithelial cells |
With KrasG12D29, 31, 32 or KrasG12D;Ink4a/ArfCo/Co29
|
Skin squamous cell carcinomas |
Keratinocytes |
Keratinocytes |
Alone 79, 80 or with PtenCo/Co80
|
Head and neck squamous cell carcinoma |
Oral epithelial cells |
Oral epithelial cells |
Alone 82
|
Esophagus and forestomach Squamous Cell Carcinoma |
Esophageal and forestomach epithelial cells |
Esophageal and forestomach epithelial cells |
Alone or with PtenCo/Co81
|
Cholangiocellular carcinoma |
Hepatocytes and bile duct epithelial cells |
Bile duct epithelial cells |
With PtenCo/Co101
|
Breast squamous cell carcinoma |
Mammary epithelial cells |
Mammary epithelial cells |
Alone 102
|
Keratocystic odontogenic tumors |
Odontoblasts or HERS cells |
Odontoblasts/HERS cells or HERS cells |
Alone 108
|