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The SENP isoforms show different affinity for the several SUMO isoforms in maturation processing and de-conjugation.
| SENP isoform | Maturation | De-conjugation |
|---|---|---|
| SENP1 | SUMO1>SUMO2>>SUMO321 | SUMO1, SUMO222, 23 |
| SENP2 | SUMO2>SUMO1, poor activity towards SUMO324, 25 | SUMO2>SUMO1, poor activity towards SUMO324, 25 |
| SENP3 | No processing activity | SUMO2, SUMO326, 27 |
| SENP5 | SUMO326;27 | SUMO124, 25 |
| SENP6 | No processing activity20, 28 | SUMO2, SUMO329 |
| SENP7 | No processing activity20, 28 | SUMO2, SUMO3>>>SUMO128 |
