Table 1.

Maternal Wild-Type and Maternal apoE^−/− Offspring Show Different Responses to Diet-Induced Hypercholesterolemia

	EC			SMC
	Mat WT	Mat KO	Sign.	Mat WT	Mat KO	Sign.
3Me-K4-H3	=	+		+	−	***
3Me-K9-H3	=	=		=	−	*
3Me-K27-H3	=	=	#	=	−	*
hSet1	+	+	#	=	−	*
SUV39H1	=	=		−	−
EZH2	N.D.	N.D.		N.D.	N.D.

Overview showing the responses to diet-induced hypercholesterolemia in maternal wild-type (Mat WT) and maternal apoE^{−/ −} (Mat KO) offspring, based on the relative number of vascular endothelial (EC) and smooth muscle cells (SMC) positive for a specific histone triple-methylation modification or expression of a lysine methyltransferase. 

+ significant up-regulation of the relative number of positively stained cells in response to diet-induced hypercholesterolemia. 

− significant down-regulation. 

= not significantly up- or down-regulated. 

N.D. not determined. 

Significant differences between the types of diet-induced responses in Mat WT versus Mat KO offspring are indicated with *(P < 0.05) and ***(P < 0.001). Significantly similar responses are indicated with ^#(P > 0.999).