Skip to main content
. 2010 Feb;176(2):679–686. doi: 10.2353/ajpath.2010.090123

Figure 6.

Figure 6

PX-866 decreases progression of lung fibrosis. Both CCSP/TGFα transgenic mice administered PX-866 4 weeks after the initiation of TGFα induction and CCSP/TGFα transgenic mice Off Dox demonstrated attenuation of fibrosis compared with vehicle-treated CCSP/TGFα mice. Photomicrographs in A are trichrome stains from two separate animals focused on low power of pleural surface and interstitial areas (top, ×2.5 magnification) and higher power of peribronchial and perivascular adventitium (bottom, ×10 magnification). All photomicrographs are representative of lungs from six mice in each group. Panel B demonstrates lung collagen in PX-866-treated mice was unchanged compared with Off Dox mice, but remained elevated compared with CCSP/− controls. *P < 0.05 compared with CCSP/− control mice; **P < 0.05 compared with vehicle-treated CCSP/TGFα transgenic mice. Data derived from 10 mice per group.