Figure 7.

PX-866 decreases progression of SMA deposition. Sections of lungs from CCSP/TGFα transgenic mice in reversal studies were stained with SMA. CCSP/TGFα transgenic mice administered vehicle demonstrate marked SMA staining in the pleural and adventitia regions while mice treated with PX-866 and Off Dox demonstrate reduced SMA staining. Upper panel is taken at ×5 magnification with lower panel at ×20 magnification. Scale bar = 100 μm. Photomicrographs are from two separate animals and are representative of lungs from five to seven mice in each group.