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. 2010 Feb;176(2):687–698. doi: 10.2353/ajpath.2010.090222

Figure 5.

Figure 5

Effects of sFas gene delivery on cardiomyocyte ultrastructure and expression of GATA-4 and sarcomeric proteins in doxorubicin cardiotoxicity. A: Electron microphotographs. Doxorubicin treatment induced marked degenerative changes, and the damage was significantly attenuated by sFas gene delivery. Scale bars = 1 μm. Graph showing the percent volume comprised of myofibrils assessed by ultrastructural morphometry. *P < 0.05 versus the sham group; #P < 0.05 versus the doxorubicin-treated group with LacZ gene transfer. B: Western blots for GATA-4, MHC, and troponin I. *P < 0.05 versus the sham group; #P < 0.05 versus the doxorubicin-treated group with LacZ gene transfer.