Figure 6.

Immunoproteasome induction in DLPFC (A–D) and WM (E–H) was correlated significantly with virological and immunological status of HIV-infected subjects. HIV-1 RNA concentrations in brain (A and E), CSF (B and F), and blood plasma (C and G) were positively correlated with PA28α levels. CD4⁺ lymphocyte counts in blood plasma were negatively correlated with PA28α levels in DLPFC (D), but not WM (H). Equivalent results for LMP7 were obtained (not illustrated). Statistics: Pearson’s correlation.